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KMID : 0614020020170010091
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Journal of Pharmaceutical Sciences (C.N.U.)
2002 Volume.17 No. 1 p.91 ~ p.95
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Evaluation of Hepatic Extraction Ratio of Green Tea Catechins in Rats
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Lim Jae-Soo
Hwang Sung-Joo
Jee Ung-Kil
Kim Dong-Chool
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Abstract
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To investigate the role of liver in the elimination of green tea catechins, the hepatic extraction ratio of epigallocatechin gallate, epigallocatechin, and epicatechin gallate was investigated following intraduodenal administration of green tea catechin extracts in Sprague-Dawley rats. The plasma concentrations of the catechins in portal and systemic circulations were determined simultaneously in the same rat to evaluate the hepatic extraction ratio. The values of hepatic extraction ratio of epigallocatechin gallate, epicatechin gallate, and epicatechin were 0.54, 0.28, and 0.51, respectively. Therefore, it is suggested that the hepatic clearance plays a major role in the elimination of epigallocatechin gallate and epicatechin.
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KEYWORD
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Green tea catechins, hepatic extraction ratio, hepatic clearance
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